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AgeForce® Nitric Oxide Blast - Nitric Oxide Boosters, Nitric Oxide Supplement, Nitric Oxide Benefits

Nitric Oxide

More Nutrient Rich Blood To Your Muscles With No Additional Cardiac Demand

Because of its impressive ability to dilate human blood vessels in a way that allows for significant increases in blood and thus nutrient and oxygen flow to the musculature and other organs, nitric oxide (NO) has long been thought of exclusively as a "pump" supplement. A closer look at the research, however, reveals that it would be shortsighted to think of NO boosters like our very own "Nitric Oxide Booster" Patch as mere "pump supplements". After all, nitric oxide is an essential signaling molecule with health effects that go way beyond the provision of insane pumps at the gym:

  • The blood vessel dilating nitric oxide isNO and your cardiovascular health: Nitric oxide helps you maintain and achieve normal blood pressure levels. Eventually, even the detrimental effects of smoking are partly mediated via the smoking-impaired reduction of endothelial nitric oxide synthesis (Barua. 2001).

Optimal NO levels will thus protect you from all the potentially fatal secondary diseases (heart disease, stroke, etc.) that have been associated with chronic hypertension (Haynes. 1993; Stamler. 1994).

  • NO and your immune system: Despite the fact that "today, there is no simple, uniform picture of the function of NO in the immune system" (Bogdan. 2001). There's no doubt about the important role of nitric oxide in the maintenance and function of our immune system. It's after all nitric oxide that's used by our body's pathogen police, the white blood cells, to attack viruses, bacteria, fungi, protozoa, helminths, and even tumor cells (MacMicking. 1997).

  • NO and your metabolic health: Next to the previously discussed health effects, nitric oxide has also been identified as an important regulator of glucose control. In this regard, NO's ability to increase glucose transport in skeletal muscle (Balon. 1997) is particularly intriguing and could be great interest to both, athletes and sedentary, often overweight individuals (Bogdanski. 2012).

Some scientists even go so far as to speculate that the natural increase in NO production that occurs with acute and chronic training (Jungersten. 1997) may be partly responsible for the well-known exercise-induced improvements of blood glucose management. The impaired NO production in diabetics, on the other hand, is part of the vicious cycle that makes it so difficult for diabetics to Arginine supplementation leads to significant normalize their glucose levels and lose weight.

  • NO and your brain / CNS health: Without nitric oxide our brains' neurotransmitters system cannot function properly. Studies that used an NO-synthase inhibitor, which prevents the local conversion of precursor molecules as you can find them in our "Nitrix Oxide Booster" Patch to nitric oxide, found that a lack of nitric oxide production inhibits the release of neurotransmitters like serotonin, which makes you happy, and dopamine, which gets you going (Garthwaite. 1991; Yun. 1997). Needless to say that this may have far-reaching negative effects on how you feel and behave.

Nitric oxide is also heavily involved in the differentiation and regeneration of cells of our nervous system; and even though "the precise functions of NO in developing and regenerating neurons remain unclear" (Bredt. 1994), scientists know for sure that reduced nitric oxide levels as they occur with aging, diabetes and several other common ailments promote the progression of cognitive decline.

  • NO and your sexual function: It stands a nitric oxide mediated increase in vasodilation can have profound beneficial effects on male sexual function (Burnett. 1992; Toda. 2005). It's thus not surprising that herbs and foods that improve the availability of nitric oxide have been used as 'natural Viagra' for centuries (Cormio. 2011; Bryan. 2015). Diabetes or smoking, on the other hand, mediate their ill effects on erectile function in men at least partly by their detrimental effect on penile nitric oxide synthase (Xie. 1997; Liu. 2015).

Men are yet not the only ones whose sexual function critically depends on the presence of sufficient levels of nitric oxide and its influence on the previously discussed production of serotonin and dopamine, as well as its direct impact on the production of fertility hormones via the NO-induced release of the luteinizing hormone releasing hormone aka "LHRH" (Mani. 1994).

  • NO and your athletic performance: While the best-known effect of Nitric Oxide supplements within the fitness community is, as previously pointed out, their ability to increase "the pump", the athletic / performance effects of powerful nitric oxide boosters like our "Nitric Oxide Booster" Patch go well beyond improvements of the way you look and feel during your workouts.

The reformulated nitric oxide patch feeds into both pathways, the arginine NO pathway (classic) and the nitrate NO pathway to maximally boost your NO levels.

Figure 3: The reformulated nitric oxide patch feeds into both pathways, the arginine
NO pathway (classic) and the nitrate NO pathway to maximally boost your NO levels.

By feeding directly and without first-pass in the liver into the "arginine > nitric oxide"- and the "nitrate > nitric oxide"-pathways, the reformulated "Nitric Oxide Booster" Patch induces significantly more pronounced increases in NO production than any of the first generation arginine-only products you may have tried.

10-km time-trial performance of 10 trained cyclists with (A) individual data and (B) mean power output after 6 days on either nitrate or placebo supplement

Figure 4: 10-km time-trial performance of 10 trained cyclists with (A) individual data and
(B) mean power output after 6 days on either nitrate or placebo supplement (Cermak. 2012).

The corresponding increases in nitric oxide production are profound enough to trigger increases in performance not just in sedentary and moderately trained individuals (cf. Besco. 2012), but also in highly trained individuals whose NO production is naturally elevated (Jungersten. 1997; Cermak. 2012 | cf. Figure 4).

References:

Balon, Thomas W., and Jerry L. Nadler. "Evidence that nitric oxide increases glucose transport in skeletal muscle." Journal of Applied Physiology 82.1 (1997): 359-363.

Barua, Rajat S., et al. "Dysfunctional endothelial nitric oxide biosynthesis in healthy smokers with impaired endothelium-dependent vasodilatation." Circulation 104.16 (2001): 1905-1910.

Besco, Rauúl, et al. "The effect of nitric-oxide-related supplements on human performance." Sports medicine 42.2 (2012): 99-117.

Bogdan, Christian. "Nitric oxide and the immune response." Nature immunology 2.10 (2001): 907-916.

Bogdanski, P., et al. "Effect of 3-month L-arginine supplementation on insulin resistance and tumor necrosis factor activity in patients with visceral obesity." Eur Rev Med Pharmacol Sci 16.6 (2012): 816-823.

Bryan, Nathan S. "The Importance of Nitric Oxide for Sexual and Exercise Performance and its Role in Adenosine Triphosphate Production." Anti-Aging Therapeutics Volume XVI 16 (2015).

Burnett, Arthur L., et al. "Nitric oxide: a physiologic mediator of penile erection." Science 257.5068 (1992): 401-403.

Cormio, Luigi, et al. "Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction." Urology 77.1 (2011): 119-122.

Fu, Wenjiang J., et al. "Dietary L-arginine supplementation reduces fat mass in Zucker diabetic fatty rats." The Journal of nutrition 135.4 (2005): 714-721.

Garthwaite, John. "Glutamate, nitric oxide and cell-cell signalling in the nervous system." Trends in neurosciences 14.2 (1991): 60-67.

Haynes, William G., et al. "Inhibition of nitric oxide synthesis increases blood pressure in healthy humans." Journal of hypertension 11.12 (1993): 1375-1380.

Jungersten, Lennart, et al. "Both physical fitness and acute exercise regulate nitric oxide formation in healthy humans." Journal of Applied Physiology 82.3 (1997): 760-764.

Liu, Chunhui, et al. "Endothelial Nitric Oxide Synthase Polymorphisms and Erectile Dysfunction: A Meta‐Analysis." The journal of sexual medicine (2015).

Liu, Donald, et al. "UVA irradiation of human skin vasodilates arterial vasculature and lowers blood pressure independently of nitric oxide synthase." Journal of Investigative Dermatology 134.7 (2014): 1839-1846.

MacMicking, John, Qiao-wen Xie, and Carl Nathan. "Nitric oxide and macrophage function." Annual review of immunology 15.1 (1997): 323-350.

Mani, Shailaja K., et al. "Nitric oxide mediates sexual behavior in female rats." Proceedings of the National Academy of Sciences 91.14 (1994): 6468-6472.

Stamler, Jonathan S., et al. "Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans." Circulation 89.5 (1994): 2035-2040.

Toda, Noboru, Kazuhede Ayajiki, and Tomio Okamura. "Nitric oxide and penile erectile function." Pharmacology & therapeutics 106.2 (2005): 233-266.

Xie, Yining, et al. "Effect of long-term passive smoking on erectile function and penile nitric oxide synthase in the rat." The Journal of urology 157.3 (1997): 1121-1126.

Yun, H. Y., V. L. Dawson, and T. M. Dawson. "Nitric oxide in health and disease of the nervous system." Molecular psychiatry 2.4 (1997): 300-310.

Customer Reviews - We do not monitor or control the content of reviews but reserve the right to remove what are, in our sole opinion, clearly false statements, spam or other injurious materials that are brought to our attention. We do not adopt or endorse any review statement.
5.0/5 from 10 ratings.
Summary rating
Thanks AgeForce!
Review
I operate an international business, and my age is 72. I subscribe to anti ageing for about 3 decades. I also follow a fitness regime consisting of 80 push ups (before office) before I do dumbell (22.5kg) weight lifting, work the heavy boxing bag, followed by speedball and I take daily brisk walks of about 5Km. For years I have been on a large quantity of supplements all taken orally including DHEA, whilst I took intravenous adminstered HGH and Creme Testosterone to balance my hormones key aspect/requirement of anti ageing.

Then in early 2014 I ‘discovered’ Ageforce and switched to patches. Besides HGH, Testosterone, I also use DHEA, Nitric Oxide, to boost my energy during work outs, Creatine, patches against inflammation, libido enhancement and more. I felt fit and have been confident that the patches did what they were supposed to but I did not take blood test to check my HGH and testosterone level until 2 weeks ago thus about 5 years since I started using patches. I am excited to say that the blood test confirmed what I had subconsciously known all along which means the test result were GOOD. For HGH my IGF was 112. The range is 35-216. That places me above the median. For testosterone the result was 10.1 ng/dL. The range is 3.28-12.2ng/dL. Here my result is above the median.

All these years I have managed to keep my hormone levels balanced and retained a good degree of fitness and I enjoyed all these benefits whilst my expenses have dropped to less than a third of what I used to spend.
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1 of 1 people found the following review helpful
Great Product!
Review
Love this patch!
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0 of 0 people found the following review helpful
My Fav Patch
Review
I have been an Ageforce customer for 8 months. So far I have tried 4 different patches, none work as swiftly as the NO. This patch delivers!! I workout in the mornings so I apply it at night. I run to & from the gum and boy can I feel the difference, i'd say 10% improvement in cardio. Lactic acid buildup in the gym is decreased, allowing for extra few reps. IMO this is a required patch for workout days, regardless of other patches being used.
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2 of 3 people found the following review helpful
IMPROVED OXYGEN FLOW
Review
After receiving the Nitric Oxide and using the Patch,  a test was preformed to check my oxygen level.  I must say it was much, much improved.  I feel better  during my walks and a little exercise.  Any one needing extra oxygen needs to try the Patch.  Will order again soon.
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0 of 0 people found the following review helpful
Great Booster ! Will get you motivated.
Review
I am a 58 year old male. I have had 6 back surgeries,so I can't do a lot of the lifting that I used to,or walk for great distances, but I found I can ride bicycle. I have noticed since using the patch, I can easily go the extra mile, or 2. Thank you for this great patch and the excellent service!!!
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3 of 4 people found the following review helpful
Excellent NO booster
Review
I've tried both NItric Oxide patches, both are excellent, however the introduction of agmatine really gives it  an extra kick. Workouts have improved but it is recovery where I feel these patches excel. I also feel better on these patches, mentally and physically. If you are over 30 this will definetly help deal with stress and workouts better.
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0 of 0 people found the following review helpful
Nitric Oxide Patch for Tendonitis (Climber's/Golfer's Elbow)
Review
I noticed a significant benefit, especially after having used it for a while. I also tried another brand but the other brand didn't have as many great ingredients!
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2 of 3 people found the following review helpful
Let's get pumped up
Review
I have been a big fan of NO2 for quite some time after reading a book on the subject. It was called the new science of bodybuilding NO2 the 21 day transformation.  This stuff works.  My workouts are more intense and I recover much quicker than when I am not using these.  It's either this or drink gallons of beet juice.
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0 of 0 people found the following review helpful
Great pump!
Review
This patch worked right away for me. The pumps are insane and it really helps my endurance. I forgot to use the patch 1 day and about 10 minutes after starting my workout it dawned on my why I was winded. Very convenient and effective!
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0 of 0 people found the following review helpful
Say Yes to NO for better health and vitality in the right places
Review
 I am into exercise, I used to be athletic, playing soccer, became a late in the game at 27,  but presently I am in a maintenance routine. Staying fit as a firm believer that optimal performance requires the combines strength of physical fitness and an agile mind. I started with NO a year ago not primarily for fitness but as a potential remedy for plague formation in arteries. I had read that nitric oxide relaxes narrowed blood vessels, increasing oxygen and blood flow.

I also read that the interior surface of your arteries produce nitric oxide. When plaque builds up, this reduces your capacity to produce nitric oxide.  I had already started on HGH patches, and then I saw NO. I bought them and never looked back since. Amongst other I do dumbbell reps and after I used NO I managed to increase my reps without straining myself. Better blood flow and delivery of nutrients to muscles are behind the extra power when using NO. But better blood flow does not discriminate in the body and well I found there is a terrific bonus in sexual function. I tried Viagra before but it makes me feel flushes and slightly tense hence I give it a miss. NO is like taking Viagra via the back door minus the side effects. I have more than one reason to carry on with the wonderful patch.
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2 of 2 people found the following review helpful

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References:

Balon, Thomas W., and Jerry L. Nadler. "Evidence that nitric oxide increases glucose transport in skeletal muscle." Journal of Applied Physiology 82.1 (1997): 359-363.

Barua, Rajat S., et al. "Dysfunctional endothelial nitric oxide biosynthesis in healthy smokers with impaired endothelium-dependent vasodilatation." Circulation 104.16 (2001): 1905-1910.

Besco, Rauúl, et al. "The effect of nitric-oxide-related supplements on human performance." Sports medicine 42.2 (2012): 99-117.

Bogdan, Christian. "Nitric oxide and the immune response." Nature immunology 2.10 (2001): 907-916.

Bogdanski, P., et al. "Effect of 3-month L-arginine supplementation on insulin resistance and tumor necrosis factor activity in patients with visceral obesity." Eur Rev Med Pharmacol Sci 16.6 (2012): 816-823.

Bryan, Nathan S. "The Importance of Nitric Oxide for Sexual and Exercise Performance and its Role in Adenosine Triphosphate Production." Anti-Aging Therapeutics Volume XVI 16 (2015).

Burnett, Arthur L., et al. "Nitric oxide: a physiologic mediator of penile erection." Science 257.5068 (1992): 401-403.

Cormio, Luigi, et al. "Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction." Urology 77.1 (2011): 119-122.

Fu, Wenjiang J., et al. "Dietary L-arginine supplementation reduces fat mass in Zucker diabetic fatty rats." The Journal of nutrition 135.4 (2005): 714-721.

Garthwaite, John. "Glutamate, nitric oxide and cell-cell signalling in the nervous system." Trends in neurosciences 14.2 (1991): 60-67.

Haynes, William G., et al. "Inhibition of nitric oxide synthesis increases blood pressure in healthy humans." Journal of hypertension 11.12 (1993): 1375-1380.

Jungersten, Lennart, et al. "Both physical fitness and acute exercise regulate nitric oxide formation in healthy humans." Journal of Applied Physiology 82.3 (1997): 760-764.

Liu, Chunhui, et al. "Endothelial Nitric Oxide Synthase Polymorphisms and Erectile Dysfunction: A Meta‐Analysis." The journal of sexual medicine (2015).

Liu, Donald, et al. "UVA irradiation of human skin vasodilates arterial vasculature and lowers blood pressure independently of nitric oxide synthase." Journal of Investigative Dermatology 134.7 (2014): 1839-1846.

MacMicking, John, Qiao-wen Xie, and Carl Nathan. "Nitric oxide and macrophage function." Annual review of immunology 15.1 (1997): 323-350.

Mani, Shailaja K., et al. "Nitric oxide mediates sexual behavior in female rats." Proceedings of the National Academy of Sciences 91.14 (1994): 6468-6472.

Stamler, Jonathan S., et al. "Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans." Circulation 89.5 (1994): 2035-2040.

Toda, Noboru, Kazuhede Ayajiki, and Tomio Okamura. "Nitric oxide and penile erectile function." Pharmacology & therapeutics 106.2 (2005): 233-266.

Xie, Yining, et al. "Effect of long-term passive smoking on erectile function and penile nitric oxide synthase in the rat." The Journal of urology 157.3 (1997): 1121-1126.

Yun, H. Y., V. L. Dawson, and T. M. Dawson. "Nitric oxide in health and disease of the nervous system." Molecular psychiatry 2.4 (1997): 300-310.

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