Vitamin D + K Skin Patch
Vitamin D has long been misunderstood as a "bone builder", only. Within the last two decades, however, our understanding of the various beneficial health effects of vitamin D has changed tremendously (Christakos. 2013).
According to the latest analyses and reviews, low levels of vitamin D, which are defined as serum levels of the vitamin D metabolite 25OHD below 50nmol/L, are a serious health-issue in the US, Europe, and Asia. And despite the fact that vitamin D is produced in response to UVB exposure (sunlight) in the skin, low vitamin D levels are a serious issue in Africa, South America and the Middle East, as well (Hilger. 2014) – with potentially fatal consequences. Low levels of vitamin D have been linked to:
- bone loss, low bone mineralization, osteoporosis
- increased risk of fractures
- increased cancer risk
- reduced immunity and increases susceptibility to infections
- high risk of various autoimmune diseases ranging from asthma over irritable bowel syndrome and Crohn's Disease to multiple sclerosis
- impaired muscle function
- impaired response adaptive response to exercise
- increased diabetes risk
- impaired respiratory health
And this is only the shortlist of potential side effects of insufficient vitamin D levels. For long, scientists have been convinced that an intake of 600-800IU per day would be sufficient to maintain optimal vitamin D levels. In the last decade, more and more researchers started questioning this paradigm arguing that the low vitamin D levels we see in people all around the world would be evidence enough that supplementation is not just necessary, but mandatory.
The vitamin D council, a non-profit organization that was founded by members of the aforementioned group of researchers, for example, currently suggests to take 5,000IU of vitamin D per day.
|Vitamin D Council||Endocrine Society||Food and Nutrition Board|
|Infants||1,000 IU/day||400-1,000 IU/day||400 IU/day|
|Children||1,000 IU/day per 25lbs of body weight||600-1,000 IU/day||600 IU/day|
|Adults||5,000 IU/day||1,500-2,000 IU/day||600 IU/day, 800 IU/day for seniors|
Table 1: Recommended daily intakes from various organizations (vitamin-D-council.org)
As you can see in Table 1, this is in contrast to the conventional recommendation of the Food and Nutrition Board in the US and thus – as you would expect – controversial. Currently, the recommendation of the Endocrine Society, which amounts to 1,500-2,000 IU/day of vitamin D in form of vitamin D3 supplements, is probably the one with the most solid scientific backup.
There is yet one downside to these recommendations all three organizations tend to ignore: Humans didn't evolve to consume more than the meager. 800IU/day of vitamin D you can actually get from your diet, if you emphasize vitamin D rich over vitamin D deficient foods.
Vitamin D patches –Transdermal delivery, as the natural route to vitamin D supplementation
Naturally, we would self-produce all the vitamin D we need in the skin, where the cholesterol-based vitamin, of which most researchers by now say that it's in fact a "hormone", is produced in response to UVB exposure.
Cholesterol and the direct exposition to sunlight, both are necessary to produce vitamin D; and both are avoided by many of us, who are afraid of cardiovascular disease and skin cancer, respectively. Now, it is obviously possible to sidestep the problem by the provision of extra vitamin D in the form of pills or powders. Possible, yes! Optimal? Dozens of highly disappointing vitamin D supplementation trials in the course of which the levels of 25-OHD in the blood went up, yet without any of the hoped-for beneficial health effects, suggest otherwise.
Here at AgeForce, we believe that it's the lack of enzymatic processes and secondary metabolites which arise, when the freshly synthesized vitamin D migrates from the skin into the bloodstream (Holick. 2004). Therefore we've produced the world's first convenient and effective vitamin D patch. It delivers a steady influx of vitamin D through the skin and does thus mirror the natural passage of vitamin D through the skin.
Vitamin D and Vitamin K – A dynamic duo for bone and metabolic health
With vitamin K2 we have added the perfect synergist. Just like vitamin D, vitamin K has long been thought of as a "bone vitamin". Just like vitamin D, it has recently been identified as critically important for metabolic health. And just like it is the case for vitamin D, low levels of vitamin K have been associated with increased inflammation in men and women of all age groups (Shea. 2008).
Next to its well-researched effects on bone health (Iwamoto. 2000 & 2006) vitamin K, or rather vitamin K2, as it is included in our vitamin D patch, has been shown to improve insulin sensitivity (Choi. 2011), and scientists have long been arguing that the current recommended daily allowance for vitamin K is insufficient to provide optimal protection against vascular calcification (Schurgers. 2001). Against that background it is not really surprising that Gast et al. report in a large-scale prospective study with more than 16,000 female subjects that a high vitamin K2 intake reduces the incidence of coronary heart disease by 9%. Other studies by Gelejnse et al. (2004) show reductions of up to 52% for coronary calcification and 41% for coronary heart disease, in general.
In view of the generally low vitamin K content of the Western diet and the fact that the nutritionally more abundant vitamin K1 did not show similar heart protective effects in the aforementioned studies by Schurgers et al. and Gelejnse et al., more and more scientists argue that the provision of supplemental vitamin K2 should become routine practice – if not for everyone, then at least for people who are at high risk of coronary heart disease.
Of the various forms of vitamin K2, the short-chain form MK-4 and the longer-chain variety MK-7 appear to have the most significant health benefits. Their limited oral bioavailability is yet a problem that's particularly pronounced for MK-4, which is the most abundant form of vitamin K in brain, kidney, fat and reproductive organs (Beulen. 2013). It's transdermal application via patches is thus a logical next step to maximize the beneficial health effects of MK-4.
Ageforce Vitamin D Skin Patch - An investment into a healthier future
With AgeForce Vitamin D patch, all you need to maintain optimal levels of these two crucial vitamins are two patches per week. Once applied they will deliver a constant flux of vitamin D3 and both of the health-relevant forms of K2 which will contribute to optimal bone, cardiovascular and immune health and help optimize and maintain optimal glucose and lipid management.
Beulens, Joline WJ, et al. "The role of menaquinones (vitamin K2) in human health." British Journal of Nutrition 110.08 (2013): 1357-1368.
Choi, Hyung Jin, et al. "Vitamin K2 supplementation improves insulin sensitivity via osteocalcin metabolism: a placebo-controlled trial." Diabetes care 34.9 (2011): e147-e147.
Christakos, Sylvia, et al. "Vitamin D: beyond bone." Annals of the New York Academy of Sciences 1287.1 (2013): 45-58.
Geleijnse, Johanna M., et al. "Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study." The Journal of nutrition 134.11 (2004): 3100-3105.
Hilger, Jennifer, et al. "A systematic review of vitamin D status in populations worldwide." British Journal of Nutrition 111.01 (2014): 23-45.
Holick, Michael F. "Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease." The American journal of clinical nutrition 80.6 (2004): 1678S-1688S.
Iwamoto, Jun, Tsuyoshi Takeda, and Shoichi Ichimura. "Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis." Journal of orthopaedic science 5.6 (2000): 546-551.
Iwamoto, Jun, Tsuyoshi Takeda, and Yoshihiro Sato. "Menatetrenone (vitamin K2) and bone quality in the treatment of postmenopausal osteoporosis." Nutrition reviews 64.12 (2006): 509-517.
Schurgers, L. J., et al. "Role of vitamin K and vitamin K-dependent proteins in vascular calcification." Zeitschrift für kardiologie 90.3 (2001): 57-63.
Shea, M. Kyla, et al. "Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham Offspring Study." American journal of epidemiology 167.3 (2008): 313-320.
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I will be ordering again soon and trying the multivitamin as well. Thank you AgeForce !