Magnesium – There are many reasons to 'patch' your Mg2+ levels
Magnesium (Mg2+) is both, literally and figuratively, on everybody's lips. Still, for many of us, the amount of this vital mineral that actually makes it from the lips to the digestive tract and – often that's where the problems really begin – into our bloodstream is much smaller than it should be. In fact, many of us consume, digest, and absorb so little magnesium that many scientists believe that a widespread and still underestimated (subclinical) magnesium deficiency (hypomagnesemia) may well explain the exponential increases in cardiometabolic, neuronal, skeletal and muscle health (DiNicolantanio 2018).
Figure 1: It's not "even", but especially in the (over-)nourished industrialized world, where an under-estimated (often subclinical) magnesium deficiency is linked to an ever increasing number of ailments and diseases – ranging from harmless cramps or nervousness to heart disease, seizures, and strokes.
What's worse: The consequences for your health, your everyday, and, obviously your athletic performance, are way more far-reaching than magnesium's well-known anti-cramping and calming effects would suggest – affecting essentially all parts of the body from the brain and central nervous system (CNS), to the heart and cardiovascular system, and, obviously to skeletal muscles and bones (see Figure 1) .
You(!) may be one of the numerous people with undiagnosed magnesium deficiency
Scientific evidence that many of us don't consume, digest, and absorb enough magnesium has been accumulating over the last 50+ years.
Moreover, our dietary magnesium intakes are on progressively declining. Recent data suggests that more than a quarter of the obese and non-obese youths display severely inadequate intakes of magnesium (27% and 29%, respectively). So "inadequate", in fact, that the dietary habits of our young generation places them at a significant contemporary and future risk of developing a life-shortening, in many cases life-threatening Mg2+ deficiency, of which scientists say that it's "a principle driver of cardiovascular disease and [the contemporary] public health crisis" (DiNicolantonio 2018).
Not a problem for you? Your levels have always been fine? We hate to break it to you, but chances are that the green figure on your latest lab report may have mislead you to believe that your magnesium status was optimal, when, at this very moment, non-marginal amounts of magnesium are leeching from your cells into your blood stream to stabilize the "normal" Mg2+ levels that showed on your last blood test.
How's that? Well, unfortunately, the regular (=serum) magnesium test reflects only those less than 1% of your body's stores that are floating around freely (extra-cellular magnesium) in your blood - 99% of your total body magnesium, however, resides in the cells where only relatively expensive tests will accurately measure its concentration. The far-reaching consequences should be obvious:
"[…] our normal range of serum magnesium is inaccurate and that serum magnesium levels at the lower end of normal likely suggest marginal magnesium deficiency" (DiNicolantonio 2018).
While corresponding data for the general population is currently not available, studies in the elderly indicate that going by serum levels, alone, underestimates the prevalence of (subclinical) magnesium deficiency by a factor 2!
As early as in 1987, for example, Touitou et al. were able to show that the 10% odds of finding an individual with clinical magnesium deficiency in their study population doubled when they tested the subjects' red blood cell (a much better marker of the average intra-cellular magnesium concentrations) instead of the amount of Mg2+ in the liquid phase of the blood. Moreover, with modern tests being able to detect Mg2+ deficiencies at the cellular level more efficient- und reliably, it is not impossible to imagine than the actual rate of cellular (subclinical) magnesium deficiency is three times higher than the "low magnesium epidemic" you may have read about in the mainstream media would suggest.
"Ok, let's assume I am deficient - How bad is that for me?"
Mg2+ is the fourth most common cation in our body, and the second most common intracellular positively charged intracellular mineral (Canelas 1965). In total, the human body contains around 25 g of magnesium (Martyka 1996) which is necessary for the proper function of over 300 enzymes in our bodies (Wacker 1968). These magnesium-based enzymes are molecules that facilitate (the experts say "catalyze") vitally important chemical reactions literally everywhere in our bodies.
In this context it's worth highlighting that researchers have only recently begun to fully grasp the extent at which magnesium deficiency can contribute to the chronic low-grade inflammation (aka "inflammatory stress") that's at the heart of the ever-increasing prevalence of non-communicable diseases, like atherosclerosis, heart disease, migraines, sarcopenia (loss of muscle with aging), or the dreaded "metabolic syndrome" (MetSyn) which is diagnosed if patients have at least three out of the following health impairments: abdominal obesity, high blood pressure, high blood sugar, high serum triglycerides and low high-density lipoprotein.
As our illustration of the interaction between low magnesium levels and chronic disease in shows, these Mg2+-related chronic disease states will further reduce the absorption and increase the excretion of magnesium. The obvious consequence is a vicious cycle at the end of which an ever-increasing cellular Mg2+ shortage starts to add independently to the already increased mortality risk of diabetics, cancer sufferers and patients with all sorts of other chronic diseases (Fang 2016).
Figure 2: Relative reduction in magnesium content in selected staple foods from the American diet (based on a review by Thomas et al. 2007).
But it's by no means just this subset of the population whose lives are threatened by the progressively declining level of magnesium in their cells: With more and more people taking magnesium depleting medications, the overall decreases in the magnesium content of fresh produce (see Figure 2), and the prevalent consumption of magnesium-depleted, refined and processed foods, "the vast majority of people in modern societies are at risk for magnesium deficiency" (DiNicolantonio 2018) and hence at risk of getting caught up in the vicious circle of self-propagating magnesium deficiency, we've illustrated for you in.
To escape the vicious cycle, simply eating more magnesium isn't enough for many of us!
It is at the figuratively 'accident-prone' crossroads of magnesium intake, absorption, and cellular retention, where the new AgeForce Magnesium Patch® can help you. With its unique transdermal delivery technology, it mimics the classic Epsom-salt baths – albeit without requiring hot water and, more importantly, sitting in a bathtub for hours to wait for the skin's permeability to be lowered to the extent that's required to allow the magnesium molecules from the bathwater to penetrate a (by then) compromised stratum corneum.
Only recently, scientists have been able to show that a transdermal magnesium cream significantly increased the levels of both, serum and urinary magnesium (Kass 2017) in 25 healthy subjects (female = 13 male = 12). In the study that was conducted by researchers from the University of Hertfordshire in the UK, the subjects were randomly assigned to apply either 2 x 5ml spoonfuls of a newly formulated Mg2+ or a placebo control cream twice daily for two weeks. The corresponding paper reveals: Even though the total amount of magnesium in the crème was "only" 56mg/d, Lindsay Kass and colleagues observed significant increases in serum magnesium (+23% | ).
Obviously, the study does not necessarily confirm the efficacy of the traditional Epsom-baths – a naturopathic treatment with a long tradition that is still disputed by allopathic practitioners, what it does do, however, is to confirm that the transdermal delivery of the relatively small, but vitally important electrolyte is both, feasible and effective – provided suitable carriers are used.
Transdermal magnesium bypasses one of the most important obstacles to Mg2+ maintenance and repletion
That's good news because transporting magnesium through the skin, directly into our blood and organ tissue has one important advantage over the commonly used oral supplements: it bypasses our increasingly dysfunctional intestinal tracts and avoids potential interferences with other nutrients – including both so-called anti-nutrients and desirable minerals such as calcium, phosphorus, etc. from our diets and dietary supplements.
Obviously, this makes Age Force's transdermal Magnesium Patch® particularly interesting for those people who are at a particularly increased risk of developing a subclinical or clinical magnesium deficiency. This group of people includes, among others, …
people with celiac disease, IBS, and/or a dysbiotic intestinal tract, a condition in which the composition of the microbiome impairs the optimal use of nutrients from the diet, …
people who are forced to consume proton-pump inhibitors (PPIs | Kuipers 2009) or certain antibiotics, as well as cancer patients on chemotherapy or those patients who use immunosuppressive drugs, …
the ever-increasing number of patients who underwent a gastric bypass (weight loss) surgery, and…
those of us with certain, often hitherto undetected single-nucleotide polymorphisms (SNPs) in the genes that control the expression of the ion-transporters in the gut.
The commonly sold over-the-counter (OTC) Mg-supplements, which contain magnesium carbonate or -oxide are thus not suitable for a growing part of the population. In fact, studies suggest that even the more bioavailable forms of magnesium, such as the diarrhea-prone citrate, or the expensive glycinate, taurate, or treonate formulations are at best suboptimally digested by many members of the previously characterized at-risk group.
Needless to say: You don't have to suffer from IBS, Crohn's, and co. to benefit from 'patching' your dietary magnesium intake with the latest addition to our unique product range.
AgeForce Magnesium Patch For Ultimate Absorption
Our new Magnesium Patch® is the ideal transdermal nutritional "supplement" (in the literal sense of the word) for magnesium-conscious consumers who want to restore and maintain optimal cellular magnesium levels even in periods during which their dietary intake and/or intestinal magnesium uptake may be temporarily compromised.
Canelas, Horacio M., Luís Marques De Assis, and Francisco B. De Jorge. "Disorders of magnesium metabolism in epilepsy." Journal of neurology, neurosurgery, and psychiatry 28.4 (1965): 378.
DiNicolantonio, James J., James H. O’Keefe, and William Wilson. "Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis." Open Heart 5.1 (2018): e000668.
Fang, Xuexian, et al. "Dietary magnesium intake and the risk of cardiovascular disease, type 2 diabetes, and all-cause mortality: a dose–response meta-analysis of prospective cohort studies." BMC medicine 14.1 (2016): 210.
Kass, L., Rosanoff, A., Tanner, A., Sullivan, K., McAuley, W. and Plesset, M., 2017. Effect of transdermal magnesium cream on serum and urinary magnesium levels in humans: A pilot study. PloS one, 12(4), p.e0174817.
Kuipers, M. T., H. D. Thang, and A. B. Arntzenius. "Hypomagnesaemia due to use of proton pump inhibitors–a review." Neth J Med 67.5 (2009): 169-172.
Martyka, Z., I. Kotela, and A. Blady-Kotela. "Clinical use of magnesium." Przeglad lekarski 53.3 (1996): 155-158.
Thomas, David. "The mineral depletion of foods available to us as a nation (1940–2002)–a review of the 6th Edition of McCance and Widdowson." Nutrition and health 19.1-2 (2007): 21-55.
Touitou, Y., et al. "Prevalence of magnesium and potassium deficiencies in the elderly." Clinical chemistry 33.4 (1987): 518-523.
Wacker, Warren EC, and Alfred F. Parisi. "Magnesium metabolism." New England Journal of Medicine 278.13 (1968): 712-717.
Vormann, Jürgen. "Magnesium: nutrition and metabolism." Molecular aspects of medicine 24.1-3 (2003): 27-37