Can HGH Supplementation Really Extend Life Spans?

March 6, 2008 – Phase4 Pharmaceutical/AgeForce® Research & Development Department: We just took note of this press release and we felt that it was a very important study to show you. Important: Our company has never made any claims about HGH supplementation in connection with Anti-Aging. There are two reasons for this: First, the science and clinical studies do not support the premise that increased levels of HGH will extend life span. Secondly, the FDA frowns upon any claims made for a supplement that cannot be backed up by real science.

But the study below certainly gives all of us some food for thought…! IGF-1 is the main downstream growth factor that the liver produces from HGH in one’s system.

Not the “Fountain Of Youth”, but this certainly is an interesting study.

Genetic mutations may boost human lifespan

March 5th, 2008  Washington, Mar 5 (ANI): Researchers at the Albert Einstein College of Medicine of Yeshiva University have revealed that genetic mutations in cell-signalling pathway may boost human lifespan.

The team examined the genes involved in the activity of insulin-like growth factor (IGF-I), a hormone that is regulated by the human growth hormone.

The study conducted using the animal model showed that mutations in genes involved in the pathway restricted growth but also increased life spans.

The researchers believe that by influencing the signaling pathway might also influence human longevity.

To validate the finding, they examined 384 Ashkenazi Jewish centenarians.
Since plasma levels of IGF-I do not reflect their levels at a younger age the researchers investigated their children.

The findings revealed that the female children of the centenarians had IGF-I plasma levels that were 35 percent higher than female controls reflecting that the body was compensating for mutations in IGF-I signaling by secreting increased amounts of the hormone. The daughters of centenarians were 2.5 cm shorter than female controls.

Our findings suggest that, by interfering with IGF-I signaling, these gene mutations somehow play a role in extending the human life span, as they do in many other organisms, said Dr. Nir Barzilai, senior author of the study and director of the Institute for Aging Research at Einstein.

The research appears in March 4 issue of the Precedings of the National Academy of Sciences

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