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Human Growth Hormone Benefit For HIV Associated Wasting: A landmark study by Chiistos S. Mantozorors, M.D. DSC, and Alan C. Moses, M.D., stated in part; “Since the introduction of recombinant human growth hormone, impressive data has accrued…as medically appropriate therapy in patients in severely catabolic states (such in persons with AIDS-associated wasting. In another study Schambelan and colleagues investigated 178 patients with HIV-associated wasting. Patients who received recombinant human growth hormone at an average dose of 6 mg/d (4.3-fold more than the dose used by Waters and colleagues) for 12 weeks had a sustained increase in body weight and lean body mass, a decrease in fat, and an increase in treadmill work output. Quality of life, days of disability, and use of medical resources were the same in patients who did and those who did not receive growth hormone. No adverse effects on immune function or changes in mortality rate were seen, but the study was not designed (and probably lacked the power) to detect differences in these outcome measures.

Results of a recent study suggest that growth hormone may be able to ward off AIDS by boosting the immune system and stimulating the production of T cells. Researchers found that a daily dose of growth hormone led to a significant increase in circulating T cells in the five HIV-positive men involved in the study. Study leader Dr Laura Napolitano, said: "Finding a way to stimulate the thymus to produce T cells would help HIV-infected patients to preserve and restore their embattled immune systems." The researchers are now planning a larger study to compare the health of HIV patients taking growth hormone with others not being treated with the hormone.*
*SOURCE/REFERENCE: Reported by the BBC On The 12th July 2002.

In conclusion, despite the excitement and promise of treatment with recombinant human growth hormone for HIV-associated wasting and for growth hormone deficiency in adults, many questions remain unanswered—a frustrating situation for those desperately in need of help. Although some recent data are inconclusive, we are making progress. The studies on AIDS-associated wasting in this issue should provide a strong impetus for additional studies to define precisely who will and will not benefit from administration of recombinant human growth hormone or recombinant IGF-1.

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